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Phytocannabinoids mimic compounds which we call endocannabinoids that are produced naturally by all mammals. Cannabichromene CBC is the third most common cannabinoid found in cannabis. Like CBD, cannabichromene is non-psychoactive. Endocannabinoids, those produced naturally by our bodies, are signaling molecules.
They are technically called neurotransmitters. Hormones are a more familiar type of neurotransmitter. A vast array of neurotransmitters are produced by the nervous system in response to various states of health and also environmental factors.
They interact with receptors found on the surface of cells throughout our bodies. Their job is to instruct a cell to adjust its activities. This can include changing how cells react to other neurotransmitters. In order to manage traffic, we implement traffic signals. These include street signs, traffic lights, the lines on the road and so on.
Traffic signals inform drivers where they can and cannot travel, when they should stop and when they should go, how fast they are allowed to move and so on. The sensor triggers a controller, causing the light to change, thereby changing the behavior of the drivers approaching that intersection.
The signals from these sensors are decoded by the brain and the nervous system. If it is determined that a system has gone out of balance, the nervous system produces neurotransmitters, which travel through the bloodstream and interact with receptors on cells, instructing them to adjust their behavior.
The human endocannabinoid system ECS has two components. First is the endocannabinoid receptors found on the surface of cells throughout the body. Second is the endocannabinoids themselves that interact with those receptors.
For an example, CBD is known to mimic a signaling molecule called anandamide. Anandamide is responsible for the production and uptake of serotonin. Supplementation with CBD has been shown to raise serotonin levels.
The endocannabinoid system is vast and far-reaching. It regulates a wide array of bodily functions, from appetite regulation to sleep patterns, moods, metabolism, immune response, the lifespan of cells and much more. This is the reason that CBD seems to effect such a wide range of conditions. Below is a list of the most common cannabinoid molecules found in cannabis and some of the effects they are believed to possess. Although cannabinoids are mainly known for the role they play in the human endocannabinoid system, they also function in other ways.
For example, cannabinoids are known to have antioxidant effects. Vitamin C is an example of a common antioxidant. The process of metabolizing food can produce harmful molecules we refer to as free radicals.
These molecules can latch onto molecules in our cells, causing oxidation, the same process that causes metals to rust. Free radicals can harm or kill a cell and damage DNA. Antioxidant molecules such as cannabinoids can latch onto free radicals, rendering them harmless. Terpenes are a class of volatile hydrocarbon compounds produced by the cannabis plant as well as most other plants. Terpenes readily evaporate at room temperature, and our noses are highly sensitive to them.
Terpenes are recognized as safe for human consumption by the Food and Drug Association and are used in a wide variety of food and cosmetic products. In nature, terpenes act as both a repellent for pests and as attractants for pollinators and seed spreaders. Although terpene molecules are all very similar, each has its own unique scent and flavor. Various combinations of terpenes are responsible for the distinct aromas of cannabis strains. Terpenes can also have powerful effects on our bodies.
In fact, terpenes have been utilized by humans for millennia in a healing modality known as aromatherapy. For example, the scent of citrus is produced primarily by a combination of limonene and pinene, both of which are thought to elevate mood.
Some terpenes can act as neurotransmitters. They can also act as serotonin uptake inhibitors, enhance norepinephrine activity and increase dopamine activity, all of which are known to produce antidepressant effects. More importantly, terpenes also act on cannabinoid receptors and are known to modify the effects of cannabinoids. Although not as potent as cannabinoids in terms of their overall effects, terpenes are valuable medicinal components of cannabis. The overall effect of the rich combination of cannabinoids and terpenes is known metaphorically as The Entourage Effect.
In the case of cannabis, these cannabinoids and terpenes work together to produce a range of effects which is thought to be greater than the sum of its individual components.
More research is needed to determine the exact role that terpenes play in the overall effects of CBD oil, but it seems clear that terpenes work in concert with cannabinoids to produce a richer effect than CBD alone. These products do not have the added benefits of terpenes and other cannabinoids and do not produce the entourage effect. They are not recommended.
In just over a half century, cannabinoids have gone from obscurity to one of the most researched families of compounds in the world. The secrets of cannabinoids are vast and they run deep. After many years of study, still very little is known about how cannabinoids interact with the endocannabinoid system as well as other complex organs and systems in our bodies such as the immune system, the nervous system, the endocrine system, the cardiovascular system, the digestive system, the heart, liver, kidneys and the epidermis.
But one thing is certain — CBD does have an effect on all of these complex systems which themselves are not fully understood. In , the University of Mississippi was entrusted with growing marijuana for research by the predecessor agency to the DEA.
Only two years later, the United States declared marijuana a Class I substance with a high potential for abuse and no medicinal value. Two years after that, in , a report based on a comprehensive study by the Department of Health, Education and Welfare recommended that marijuana be removed from the scheduling system and decriminalized.
Then-President Richard Nixon rejected the recommendations. Most of the medical research done on cannabis has taken place in the 40 years since This resulted in a wave of new studies into the pharmacological effects of cannabinoids. The first endocannabinoid identified was anandamide. In , as research results began to pour in, the American Medical Student Association unanimously endorsed a statement calling for the down-scheduling of cannabis to Schedule 2.
Since that time and based on reams of data, there have been scores of attempts to pressure the federal government to relent on this matter.
So far none have been successful. The preponderance of evidence presented as a result of these studies points to one conclusion: There is a vast array of human ailments which seem to respond to CBD. Much of this research suggests that CBD might have a positive effect on these disorders. Research shows that CBD has an effect on levels of the endocannabinoid anandamide, which we mentioned earlier. Anandamide is produced by the nervous system to stimulate the uptake of serotonin in the brain.
People suffering from mood disorders such as anxiety and depression commonly show low levels of serotonin. An increase in serotonin can correspond to an increase in feelings of wellbeing. Research results suggest that CBD might provide an effective remedy for both anxiety disorders and major depression. A group of UK and Brazilian researchers studied the effects of cannabidiol on anxiety, fear and trauma. The human body relies on what we call circadian rhythms daily rhythms. Our brains determine which activities a cell should be undertaking at which times of day and our nervous system and endocrine system work together to keep cells on a daily schedule.
Particular signaling molecules such as cannabinoids are released at particular times of day to adjust activities like metabolism. In fact, many people who use CBD claim that they not only sleep better at night, but also have more energy and alertness during the day. Antioxidants are like molecular landmines that attach themselves to dangerous molecules called free radicals and render them harmless. Free radicals can damage cells and even DNA, sometimes resulting in sickness.
Another concession by the federal government involves the Department of Veterans Affairs. The amendment prohibits the VA from denying any services to veterans who use medical cannabis. The amendment reverses a VA directive that prevents VA physicians from helping veterans access medical cannabis. It also directs the VA to conduct research into the benefits of medical cannabis using whole plant cannabis and extracts. This would include CBD oil. Not all methods of administering CBD are equal.
Their effectiveness depends not only on the method of consumption and the ingredients in the product, but also the bioavailability of the CBD afforded by each method. The bioavailability of any active compound is the percentage of a given dosage that ends up in the bloodstream and is thus available for your body to use. In the case of CBD oil, the active ingredients include both cannabinoids and terpenes. A bioavailability of percent would signify that percent of the CBD in the product is available to your body.
The only way to achieve percent bioavailability is through intravenous administration — meaning injection directly into the bloodstream. Every other method of consumption will result in some percentage of the CBD becoming unavailable to the body for various reasons, such as becoming trapped in fatty tissues or metabolized broken down before it has a chance to enter the bloodstream.
Each method of CBD oil consumption has a particular range of bioavailability. A tincture is a liquid — usually an oil or an alcohol base — which has been infused with CBD oil. Tinctures are taken sublingually, meaning under the tongue. When delivered via this method, the CBD in the tincture can be absorbed directly into the bloodstream via the veins and capillaries in the tissues in your mouth.
It is generally assumed that the bioavailability of CBD in tinctures is twice that of edibles — anywhere from 10 percent to 40 percent. Aside from intravenous injection, the delivery method with the highest bioavailability is inhalation. CBD can be vaporized or atomized and inhaled. The vapor is absorbed into your lungs in the same way that oxygen is. Furthermore, the effects of inhalation are almost immediate. This is because the CBD directly enters your bloodstream through the capillary-rich tissues in the lungs in the same way that oxygen does.
The bioavailability of inhaled CBD is estimated to range between 25 percent and 60 percent. The actual number depends on the ingredients being vaporized, and other factors such as how much is inhaled in each puff, how deep it is drawn into the lungs, and how quickly it is exhaled.
There are several important factors that come into play when determining the onset time of various methods of administration of CBD oil. Because of unique genetics, no two people react to CBD oil in the same way. Furthermore, factors such as age, health, weight, circulation and metabolism can all affect the onset time of the effects of CBD oil. A factor that can be influenced by all of the above is the number of cannabinoid receptors in the body, how they are expressed, and the ability of the body to produce endocannabinoids.
An individual who expresses more receptors or produces fewer endocannabinoids may be more sensitive to CBD than someone with an abundance of endocannabinoids or a lack of receptors. The onset of edibles will typically be longer than that of tinctures, for example. As we mentioned, the onset time of inhaled CBD is virtually instantaneous. The onset time of edibles and capsules can range anywhere from 20 minutes to over an hour.
And the onset time of tinctures can take up to 20 minutes. These figures are to be considered general guidelines and will vary from person to person, as we mentioned above. As with bioavailability and onset time, the ideal dosage of CBD depends on a variety of factors including the product being used, the concentration of the CBD in the product, genetic makeup, sex, weight and so on. Some CBD products list a recommended serving size. However, without taking into account all of the variables, the recommended serving size might be far too low or possibly even too high.
In particular, the serving size will vary greatly depending on the condition for which the CBD is being consumed. A dosage that is appropriate for one product might be much different than that of a similar product.
Whereas one product might contain 10 percent CBD, another might contain twice that concentration. The most important factor to be considered, however, is that both dosage and duration of use depend largely on the reason the individual is using it. One person might simply be using CBD as a supplement to support health and wellness, while another might be using CBD for a particular ailment.
Another factor to be considered is whether or not the product being used contains a full spectrum CBD oil with terpenes. For example, a terpene known as myrcene is known to make the brain-blood barrier more permeable, effectively reducing the required dosage for brain conditions.
Given all of the above-listed factors, determining your ideal dosage requires some thinking. Taking too little will not produce the desired effect and will be a waste of time and money. Alternatively, taking more than you need may not provide additional benefits.
It will take some research and experimentation to determine an ideal dosage for a particular person. This allows you to gauge the effects of that particular product. If you switch back and forth between different products, determining a dosage will be much harder. Most experts recommend starting with 1 mg of CBD for every 20 pounds of weight. Using this rule, someone weighing pounds should start with 5 milligrams, while someone weighing over pounds can start with 10 milligrams, and so on.
If you have no issues, take another dose in the morning. If CBD oil does make you sleepy, take it at night. And if it keeps you awake at night, take it during the daytime. Oftentimes CBD oil helps with both nighttime sleep and daytime focus, in which case it can be taken multiple times throughout the day. If all goes well but you have not achieved your desired results, you can try doubling your dosage.
Each time you increase your dosage, take a few days to make note of your condition including factors such as energy, sleep, mood and pain levels. If a rise in dosage produces unwanted effects such as making you drowsy, back off to a lower dosage.
For health maintenance, experts recommend a maximum dosage somewhere between 10 and milligrams per day depending on your size, the bioavailability of the product and so on. If you are trying to help a particular ailment with CBD oil, skip all the above advice and talk to a medical professional who is knowledgeable in the use of CBD as a therapeutic agent for your condition.
Your condition may require larger doses of CBD than you would typically take for health maintenance. Also, try to reach out to people who are successfully using CBD for your condition.
There are websites dedicated to every ailment you can think of. CBD is completely non-toxic. You would have to consume quite a bit of CBD oil before it results in any truly adverse health effects.
There is no known record of anyone ever being poisoned by or overdosing on, CBD. However, taking more CBD than needed might cause some unwanted effects such as making you too relaxed for particular activities like work or sports. Combined with the pain-relieving and anti-inflammatory properties of CBD, these softgels are the perfect pick for anyone interested in natural pain management. Anyone suffering from skin conditions like eczema or acne, joint pain, or muscle soreness should take a look at Joy Organics CBD Salve.
Cat lovers stay tuned. Joy Organics is busy creating treats for your feline friends as well. In a market where CBD products are emerging almost every day, Joy Organics stands out as a company committed to bringing you some of the highest-quality, full-spectrum CBD you can find.
This family-run business complete with kids, dogs, grandkids, and grand dogs is dedicated not only to creating the best CBD products available, but also to giving back. Experience the Joy Organics difference for yourself.
When it comes to CBD products, quality is everything. In this rapidly growing industry there are many companies basically selling snake oil slapped with a label claiming Ever thought of using CBD as part of your regular skincare routine?
Your email address will not be published. This site uses Akismet to reduce spam. Learn how your comment data is processed. It gave me just the boost I needed while having a relaxing effect, and I was so pleased that I ordered the pack.
It also has a pleasant flavor! Thanks for your comment. I would like to share some information with the community of Fort Collins… Folium Biosciences is the manufacturer of Joy Organics product line. Folium Biosciences fully discloses all the ingredients in the catalog on their website. We are now working to update all of our labels so that our customers have the most accurate ingredients for our products.
After seeing the success of her products for dogs, she set her eyes on creating products for cats and other animals as well. This product is not for use by or sale to persons under the age of This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor's advice should be sought before using this and any supplemental dietary product.
All trademarks and copyrights are property of their respective owners and are not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Individual weight loss results will vary. Void Where Prohibited by Law. Marketing and Web Design Partner: Each of our hemp oil droplets is between 4 to times smaller than the industry standard.
Our solution was to create a water-soluble nanoemulsion technology. This patent-pending technology transforms active compounds into nano-sized emulsions. This is better for you and your wallet. No Risk — All products come with a 30 day money back guarantee. High Absorption — Our softgels are 4x more absorbable than a standard tincture oil.
World-Class Customer Support — Here for you to make sure your questions are answered! Full Spectrum — All products include all of the cannabinoids present in the hemp plant.
Consistency — All our hemp oil comes from the exact same extraction process in the same facility, which ensures consistency. Every Batch is Tested — Each batch is tested to ensure the highest quality hemp oil available without any metals, pesticides or THC.
Better process, better products, better results It's time you experience the Joy Organics difference. CBD Softgels All our softgels utilize our proprietary nanoemulsion technology to produce the smallest and most absorbable particle size in the industry. CBD Salve Rub our salve directly onto the skin for fast relief of inflammation, skin irritation, or muscle or joint pain.
What is CBD Oil?
Joy Organic's CBD oil is made from Colorado-grown organic hemp. This means that the company's products are produced following the strictest guidelines . see companies make a salve in one strength, so it's great that Joy's has options. Joy Smith. Guest Writer. Founder of Joy Organics. October 31 Great CBD oil companies tend to excel in five key areas. It may cost more, but in my experience, it's worth it to provide the option of non-psychoactive product. Joy Organics, a premium CBD products company, has announced their new aware of the benefits of CBD when looking for a solution to treat her aching problems, they might assume that one brand is as good as the next.