If you are struggling with chronic pain, one of the safest and most effective options could be . Benefits of high-THC strains for treating pain. Cannabis health information including its use as a treatment for Leafly Blackberry Kush cannabis strain tile Leafly Blackberry Kush cannabis strain effects Dynamite is another high-THC strain that blows pain and cramping. What are the best cannabis strains for chronic pain? CBD does not cause a high, although it does interact with pain receptors in the brain to.
high-THC for treating pain Benefits strains of
So here is a Look at THC vs CBD for fibro symptoms, and a breakdown of the most common fibro symptoms with the best strains to treat them. Before we get into the breakdown of symptoms and strains, here is a closer look at marijuana and cannabinoids.
As a side note: With the great increase in strains and hybrids, it may be more difficult to make broad generalizations, but we are somewhat forced to do so. Also, Cannabis has such a complex chemical composition with cannabinoids, terpenes, etc, and each acts differently on the body. Strain effects can vary from one crop or dispensary to the next. Cannabis has two major cannabinoids that are used to regulate what your body will feel.
The plant actually has many more cannabinoids that can have benefits for many other purposes. Several whole plant hemp oils can be purchased that can give you access to those compounds without the psychoactive effects of cannabis. Tetrahydrocannabinol THC is a chemical found in marijuana. Generally speaking, Higher THC usually means a more euphoric and head-heavy high. THC dominant strains are also responsible for an energetic feeling that can be as effective as caffeine.
CBD is the chemical in weed that is responsible for fighting inflammation, muscle spasms, anxiety, depression, cancer, and oxidation.
CBD is one of the most beneficial medicinal compounds in cannabis. For fighting pain or insomnia, you want a strain with a higher CBD content. There are two varieties of Marijuana plants, and they are Sativa and Indica. The two are very different and they work on the body different ways. Most Indica varieties have a higher CBD content that is much better for pain. Most sativa varieties are higher in THC and tend to be more head high. These strains are a combination of the two, and they give the benefits of both.
When we are dealing with pain in regard to fibromyalgia, we usually mean neurological pain. Most of the strains that are good for treating pain are Indica in variety, and heavier in CBD in chemical makeup.
However, THC can be very helpful for making the effects last longer, and the head high can make it easier to cognitively reframe your pain, making it less intense. Most of the recommendations for pain are an indica and CBD dominant strains, but hybrids work well too. Critical Mass is one of the very best strains of Indica for pain. It is high in CBD, and is also great for relieving stress and anxiety. This is a great strain for totally relaxation without losing your cognitive abilities.
Harlequin is a Sativa dominant variety, but a CBD dominant strain. This strain is the best of both worlds without the psychoactive properties of most Sativa dominant strains. Cannatonic is a hybrid strain that is CBD dominant. It is excellent for pain, and can also be used for stress or muscle spasms. Unlike pain, fighting fatigue requires a THC dominant strains.
Therefore, there are not any indica strain recommendations for fatigue here. However, it is always possible to combine a high energy strain with your favorite CBD dominant pain-fighting strain to see what results you get. There is an Indica dominant strain that goes by the same name, but Sativa is the ticket for fighting fatigue.
White Widow is one of the most popular strains on planet earth. This strain is great for a burst of energy that will get you moving, yet the CBD content helps to limit the psychoactive effects. There are different kinds of focus that Marijuana can give you. Cinex is a strain that will give you a clear headed ability to hyper-focus. This strain also boosts creativity. For those that tend to get paranoid from THC, this might heighten that sensation, so be careful.
This strain gives you a burst of clarity and creativity, while the CBDs from the indica mellow out the euphoria and help the body feel good. Great for fibro fog and chronic pain. True OG is the CBD dominant strain for those that have thoughts racing through the brain, yet want to calm the noise and focus on a single task. This strain is also great for pain and insomnia, which makes it a great all-around strain for Fibromyalgia. When you need energy, you look for a THC dominant strain, but when you are looking to go to sleep, you need a CBD dominant strain.
Similarly, no withdrawal effects were noted in a subset of patients who voluntarily stopped the medicine abruptly. Upon resumption, benefits resumed at the prior established dosages.
In a Phase II double-blind, randomized, placebo-controlled, 5-week study of 56 rheumatoid arthritis patients with Sativex Blake et al , employed nocturnal treatment only to a maximum of 6 sprays per evening In a study of spinal injury pain, NRS of pain were not statistically different from placebo, probably due to the short duration of the trial, but secondary endpoints were clearly positive Table 1.
Finally, in an RCT of intractable lower urinary tract symptoms in MS, accompanying pain in affected patients was prominently alleviated Table 1. Common adverse events AE of Sativex acutely in RCTs have included complaints of bad taste, oral stinging, dry mouth, dizziness, nausea or fatigue, but do not generally necessitate discontinuation, and prove less common over time. While there have been no head-to-head comparative RCTs of Sativex with other cannabinoid agents, certain contrasts can be drawn.
Sativex Rog et al and Marinol Svendsen et al have both been examined in treatment of central neuropathic pain in MS, with comparable results Table 1. However, adverse events were comparable or greater with Marinol than with Sativex employing THC dosages some 2. Similarly, while Sativex and smoked cannabis have not been employed in the same clinical trial, comparisons of side effect profiles can be made on the basis of SAFEX studies of Sativex for over a year and up to several years in MS and other types of neuropathic pain Russo b ; Wade et al , and government-approved research programs employing standardized herbal cannabis from Canada for chronic pain Lynch et al and the Netherlands for general conditions Janse et al ; Gorter et al over a period of several months or more.
As is evident in Figure 2 Figure 2 , all adverse events are more frequently reported with herbal cannabis, except for nausea and dizziness, both early and usually transiently reported with Sativex see Russo b for additional discussion. Comparison of adverse events AE encountered with long term therapeutic use of herbal cannabis in the Netherlands Janse et al ; Gorter et al and Canada Lynch et al , vs that observed in safety-extension SAFEX studies of Sativex oromucosal spray Russo ; Wade et al Phytocannabinoids are lipid soluble with slow and erratic oral absorption.
While cannabis users claim that the smoking of cannabis allows easy dose titration as a function of rapid onset, high serum levels in a short interval inevitably result. This quick onset is desirable for recreational purposes, wherein intoxication is the ultimate goal, but aside from paroxysmal disorders eg, episodic trigeminal neuralgia or cluster headache attack , such rapid onset of activity is not usually necessary for therapeutic purposes in chronic pain states.
The vast majority of subjects in Sativex clinical trials do not experience psychotropic effects outside of initial dose titration intervals Figure 2 and most often report subjective intoxication levels on visual analogue scales that are indistinguishable from placebo, in the single digits out of Wade et al Thus, it is now longer tenable to claim that psychoactive effects are a necessary prerequisite to symptom relief in the therapeutic setting with a standardized intermediate onset cannabis-based preparation.
Intoxication has remained a persistent issue in Marinol usage Calhoun et al , in contrast. Recent controversies have arisen in relation to non-steroidal anti-inflammatory drugs NSAID , with concerns that COX-1 agents may provoke gastrointestinal ulceration and bleeding, and COX-2 drugs may increase incidents of myocardial infarction and cerebrovascular accidents Fitzgerald ; Topol Frequent questions have been raised as to whether psychoactive drugs may be adequately blinded masked in randomized clinical trials.
Internal review and outside analysis have confirmed that blinding in Sativex spasticity studies has been effective Clark and Altman ; Wright Sativex and its placebo are prepared to appear identical in taste and color. Great public concern attends recreational cannabis usage and risks of dependency. The addictive potential of a drug is assessed on the basis of five elements: Drug abuse liability DAL is also assessed by examining a drug's rates of abuse and diversion.
US Congress placed cannabis in Schedule I of the Controlled Substances Act in , with drugs categorized as addictive, dangerous, possessing severe abuse potential and no recognized medical value. Marinol was placed in Schedule II, the category for drugs with high abuse potential and liability to produce dependency, but certain recognized medical uses, after its FDA approval in Marinol was reassigned to Schedule III in , a category denoting a lesser potential for abuse or lower dependency risk after documentation that little abuse or diversion Calhoun et al had occurred.
Nabilone was placed and has remained in Schedule II since The degree to which a drug is reinforcing is determined partly by the by the rate of its delivery to the brain Samaha and Robinson Sativex has effect onset in 15—40 minutes, peaking in a few hours, quite a bit slower than drugs of high abuse potential. It has been claimed that inclusion of CBD diminishes psychoactive effects of THC, and may lower potential drug abuse liability of the preparation see Russo b for discussion.
Prior studies from Sativex clinical trials do not support the presence reinforcement or euphoria as problems in administration Wade et al Certain facets of acute cannabinoid exposure, including tachycardia, hypothermia, orthostatic hypotension, dry mouth, ocular injection, intraocular pressure decreases, etc.
No dose tolerance to the therapeutic effects of Sativex has been observed in clinical trials in over patient-years of administration. Additionally, therapeutic efficacy has been sustained for several years in a wide variety of symptoms; SAFEX studies in MS and peripheral neuropathic pain, confirm that Sativex doses remain stable or even decreased after prolonged usage Wade et al , with maintenance of therapeutic benefit and even continued improvement.
Debate continues as to the existence of a clinically significant cannabis withdrawal syndrome with proponents Budney et al , and questioners Smith While symptoms recurred after 7—10 days of abstinence from Sativex, prior levels of symptom control were readily re-established upon re-titration of the agent Wade et al Overall, Sativex appears to pose less risk of dependency than smoked cannabis based on its slower onset, lower dosage utilized in therapy, almost total absence of intoxication in regular usage, and minimal withdrawal symptomatology even after chronic administration.
No known abuse or diversion incidents have been reported with Sativex to date as of November Cognitive effects of cannabis have been reviewed Russo et al ; Fride and Russo , but less study has occurred in therapeutic contexts. Effects of chronic heavy recreational cannabis usage on memory abate without sequelae after a few weeks of abstinence Pope et al Studies of components of the Halstead-Reitan battery with Sativex in neuropathic pain with allodynia have revealed no changes vs placebo Nurmikko et al , and in central neuropathic pain in MS Rog et al , 4 of 5 tests showed no significant differences.
While the Selective Reminding Test did not change significantly on Sativex, placebo patients displayed unexpected improvement. Slight improvements were observed in Hospital Anxiety and Depression Scales depression and anxiety scores were noted with Sativex in MS patients with central neuropathic pain Rog et al , although not quite statistically significant. No long-term mood disorders have been associated with Sativex administration.
Debate continues with regard to the relationship between cannabis usage and schizophrenia reviewed Fride and Russo An etiological relationship is not supported by epidemiological data Degenhardt et al , but if present, should bear relation to dose and length of high exposure. It is likely that lower serum levels of Sativex in therapeutic usage, in conjunction with anti-psychotic properties of CBD Zuardi and Guimaraes , would minimize risks.
Children and adolescents have been excluded from Sativex RCTs to date. SAFEX studies of Sativex have yielded few incidents of thought disorder, paranoia or related complaints. Adverse effects of cannabinoids on immune function have been observed in experimental animals at doses 50— times the psychoactive level Cabral In four patients using herbal cannabis therapeutically for over 20 years, no abnormalities were observed in leukocyte, CD4 or CD8 cell counts Russo et al Investigation of MS patients on Cannador revealed no major immune changes Katona et al , and similarly, none occurred with smoked cannabis in a short-term study of HIV patients Abrams et al Hematological measures have been normal in all Sativex RCTs without clinical signs of immune dysfunction.
Concerns are frequently noted with new drug-drug interactions, but few have resulted in Sativex RCTs despite its adjunctive use with opiates, many other psychoactive analgesic, antidepressant and anticonvulsant drugs Russo a , possibly due to CBD ability to counteract sedative effects of THC Nicholson et al Thus, Sativex should be safe to use in conjunction with other drugs metabolized via this pathway.
The Sativex product monograph in Canada http: Given that THC is the most active component affecting such abilities, and the low serum levels produced in Sativex therapy vide supra , it would be logical that that patients may be able to safely engage in such activities after early dose titration and according to individual circumstances, much as suggested for oral dronabinol. This is particularly the case in view of a report by an expert panel Grotenhermen et al that comprehensively analyzed cannabinoids and driving.
Prior studies document that 4 rapid oromucosal sprays of Sativex greater than the average single dose employed in therapy produced serum levels well below this threshold Russo b. Sativex is now well established as a cannabinoid agent with minimal psychotropic effect. These include anti-emetic effects, well established with THC, but additionally demonstrated for CBD Pertwee , the ability of THC and CBD to produce apoptosis in malignant cells and inhibit cancer-induced angiogenesis Kogan ; Ligresti et al , as well as the neuroprotective antioxidant properties of the two substances Hampson et al , and improvements in symptomatic insomnia Russo et al The degree to which cannabinoid analgesics will be adopted into adjunctive pain management practices currently remains to be determined.
Given their multi-modality effects upon various nociceptive pathways, their adjunctive side benefits, the efficacy and safety profiles to date of specific preparations in advanced clinical trials, and the complementary mechanisms and advantages of their combination with opioid therapy, the future for cannabinoid therapeutics appears very bright, indeed. National Center for Biotechnology Information , U.
Ther Clin Risk Manag. Author information Copyright and License information Disclaimer. This article has been cited by other articles in PMC. Abstract This article reviews recent research on cannabinoid analgesia via the endocannabinoid system and non-receptor mechanisms, as well as randomized clinical trials employing cannabinoids in pain treatment. Introduction Chronic pain represents an emerging public health issue of massive proportions, particularly in view of aging populations in industrialized nations.
Cannabinoids and analgesic mechanisms Cannabinoids are divided into three groups. Open in a separate window. Molecular structures of four cannabinoids employed in pain treatment. Available cannabinoid analgesic agents and those in development Very few randomized controlled trials RCTs have been conducted using smoked cannabis Campbell et al despite many anecdotal claims Grinspoon and Bakalar Table 1 Results RCTs of cannabinoids in treatment of pain syndromes.
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The Strongest Weed for Pain Relief
high thc strains better for pain relief concentration of THC in a person's blood, it also seemed to counteract the pain relieving effects of THC. The 3 top strains of marijuana for pain relief. We discuss what each strain will provide in the way of effects, and which strains are best for general pain and. As a natural pain-relief drug, some experts consider cannabis more suitable for your body than the synthetic The Predominant Effects of High-THC Strains.